Baele G, Beke R, Barbier F
Thromb Haemost. 1980 Oct 31;44(2):62-4.
In a series of in vitro experiments, the influence of bile salts on platelet aggregation by ADP or by collagen and on serotonin-14C release by collagen, was studied. Sodium salts of the following bile acids showed a clear inhibitory effect: glycochenodeoxycholic acid, taurochenodeoxycholic acid, glycocholic acid, taurocholic acid and cholic acid. Lowering the pH of the platelet-rich plasma resulted in decrease platelet aggregation by ADP and by collagen. Bile salts further enhanced the inhibitory effect of pH change. In contrast the sodium salt of chenodeoxycholic acid was the sole aggregation inducing bile salt we studied. Relating the above studies to the clinical situation of upper gastroduodenal mucosal haemorrhage, we suggest that biliary reflux as well as the acidic environment may contribute to a poor haemostatic response by impaired platelet aggregation in the upper gastrointestinal tract of otherwise normal human subjects.
在一系列体外实验中，研究了胆汁盐对二磷酸腺苷（ADP）或胶原诱导的血小板聚集以及胶原诱导的血清素-14C释放的影响。以下胆汁酸的钠盐显示出明显的抑制作用：甘氨鹅去氧胆酸、牛磺鹅去氧胆酸、甘胆酸、牛磺胆酸和胆酸。降低富血小板血浆的pH值会导致ADP和胶原诱导的血小板聚集减少。胆汁盐进一步增强了pH值变化的抑制作用。相比之下，鹅去氧胆酸钠盐是我们研究的唯一一种诱导聚集的胆汁盐。将上述研究与上消化道十二指肠黏膜出血的临床情况相关联，我们认为胆汁反流以及酸性环境可能通过损害正常人类受试者上消化道中血小板的聚集而导致止血反应不佳。
