Pratt P C
Monogr Pathol. 1978;19:43-57.
The morphology and sequential evolution of the pulmonary lesions in respiratory distress syndrome have been reviewed. Reasons have been presented to support the conclusion that these lesions are in the main produced by toxic effects of oxygen rather than the underlying disease process which initiated the episode of respiratory failure. The mechanism of oxygen toxicity has been briefly reviewed. The implication of these considerations is that in any patient with acute respiratory impairment, oxygen should be used as therapy only if it is required to prevent death from hypoxia and should be used in the lowest possible effective dose. As the patient improves and arterial oxygen tension rises this dose should be promptly reduced.
对呼吸窘迫综合征肺部病变的形态学及连续演变过程进行了回顾。已提出理由支持以下结论：这些病变主要是由氧的毒性作用所致，而非引发呼吸衰竭发作的潜在疾病过程。简要回顾了氧中毒的机制。这些考虑因素的意义在于，对于任何急性呼吸功能损害的患者，仅在需要预防因缺氧导致死亡时才可将氧用作治疗手段，且应以尽可能低的有效剂量使用。随着患者病情好转且动脉血氧张力升高，应迅速降低该剂量。
