Giordano M, Ara M, Rossiello R, Cicala C, Valentini G
Z Rheumatol. 1980 Jul-Aug;39(7-8):236-50.
A 25 year old suffering from eosinophilic fasciitis is reported. This patient showed periostitis at some bones and myatrophy of thenar and hypothenar besides the typical manifestations related to the involvement of fascia and nearby tissues. On the whole these manifestations reduced the patient's mobility seriously. The typical humoral findings of eosinophilic fasciitis were present, i. e. remarkable eosinophilia, hypergammaglobulinemia with rise of Ig G, and inflammatory serum alterations. Furthermore an increase urinary hydroxyproline excretion was found which means an altered collagen metabolism. This is obviously related to collagen accumulation that in this patient was observed at fascia, perimysium and in the subcutaneous tissue. Ig G deposits were found in the fascia. The reported case raised some problems of differential diagnosis with polymyositis, progressive systemic sclerosis, localized scleroderma and, perhaps, mixed connective tissue disease.
报道了一名25岁的嗜酸性筋膜炎患者。该患者除了有与筋膜及附近组织受累相关的典型表现外，还出现了某些骨骼的骨膜炎以及大鱼际和小鱼际肌萎缩。总体而言，这些表现严重降低了患者的活动能力。嗜酸性筋膜炎典型的体液检查结果存在，即显著的嗜酸性粒细胞增多、IgG升高导致的高球蛋白血症以及炎症性血清改变。此外，发现尿羟脯氨酸排泄增加，这意味着胶原代谢改变。这显然与该患者在筋膜、肌束膜和皮下组织中观察到的胶原积聚有关。在筋膜中发现了IgG沉积。该报道病例提出了与多发性肌炎、进行性系统性硬化症、局限性硬皮病以及可能的混合性结缔组织病进行鉴别诊断的一些问题。
