Konturek S J, Biernat J, Kwiecień N, Oleksy J
Gastroenterology. 1975 Mar;68(3):448-54.
The effect of glucagon on gastric acid and pepsin secretion, basal or stimulated by a meal, pentagastrin and histamine, was studied in duodenal ulcer patients. Intravenous glucagon infused in graded doses ranging from 6.2 to 50 mug per kg-hr produced a dose-related inhibition of pentagastrin-induced acid secretion reaching about 40% of the control level at the dose of 50 mug per kg-hr. Acid inhibition was paralleled by a decrease in the pepsin output and serum calcium level and was accompanied by a rise in the blood glucose concentration. Glucagon used in a standard dose of 25 mug per kg-hr produced about 50% inhibition of acid secretion induced by a meal (measured by intragastric titration) accompanied by a significant decrease in the serum gastrin level measured by radioimmunoassay. Histamine-induced secretion was only slightly inhibited by glucagon, and the degree of inhibition for acid (25%) and pepsin (20%) secretion was statistically insignificant.
在十二指肠溃疡患者中，研究了胰高血糖素对基础胃酸和胃蛋白酶分泌以及由进食、五肽胃泌素和组胺刺激引起的胃酸和胃蛋白酶分泌的影响。以每千克每小时6.2至50微克的分级剂量静脉输注胰高血糖素，对五肽胃泌素诱导的胃酸分泌产生剂量相关的抑制作用，在每千克每小时50微克的剂量下，抑制作用达到对照水平的约40%。胃酸抑制伴随着胃蛋白酶输出量和血清钙水平的降低，并伴有血糖浓度升高。以每千克每小时25微克的标准剂量使用胰高血糖素，对进食诱导的胃酸分泌（通过胃内滴定法测量）产生约50%的抑制作用，同时通过放射免疫测定法测量的血清胃泌素水平显著降低。组胺诱导的分泌仅受到胰高血糖素的轻微抑制，对胃酸（25%）和胃蛋白酶（20%）分泌的抑制程度在统计学上无显著意义。
