Birns J W, Honrubia V
Am J Otolaryngol. 1980 Nov;1(5):418-25. doi: 10.1016/s0196-0709(80)80023-8.
The differential effect of halothane on the characteristics of fast and slow components of vestibular nystagmus was investigated in rabbits. Eye movements were monitored using the "magnetic search coil" method and evaluated with the aid of a laboratory minicomputer. Low concentrations of halothane act preferentially on the fast component. There is a shift of the position threshold of fast component generation toward the periphery of the orbit and a diminution of the eye velocity during this nystagmus phase. Higher steady state concentrations of halothane reduced the velocity of the slow components whereby there is an increase in the amplitude of stimulation necessary to produce vestibulo-ocular responses of a magnitude to exceed the threshold of fast components. The results support the hypothesis that there are independent neural pathways for the production of fast and slow components of nystagmus whose neurons have different sensitivities to anesthetic agents.
研究了氟烷对家兔前庭眼震快慢成分特征的不同影响。采用“磁搜索线圈”方法监测眼动，并借助实验室微型计算机进行评估。低浓度氟烷优先作用于快成分。快成分产生的位置阈值向眼眶周边移动，且在此眼震阶段眼速度降低。较高稳态浓度的氟烷降低了慢成分的速度，从而产生前庭眼反应所需的刺激幅度增加，该反应幅度超过快成分阈值。结果支持以下假说：存在产生眼震快慢成分的独立神经通路，其神经元对麻醉剂具有不同敏感性。
