Fish K, Sievenpiper T, Rice S A, Wharton R S, Mazze R I
Anesthesiology. 1980 Dec;53(6):481-8. doi: 10.1097/00000542-198012000-00008.
To assess the potential for producing nephrotoxicity in rats with abnormal renal function, the renal effects of enflurane or halothane anesthesia, 1 MAC for two hours, were examined in six groups of six Fischer 344 rats each with surgically induced chronic renal impairment. As an additional predisposing factor, gentamicin, 5 mg/kg/day, was administered for one week before and for one week after anesthesia to three of the groups, one anesthetized with enflurane, one anesthetized with halothane, and one unanesthetized. No significant change in renal function could be attributed to either anesthetic agent. Serum inorganic fluoride levels four hours and 24 hours after enflurane anesthesia were similar in the gentamicin-treated and the non-gentamicin-treated groups. Clinically small but statistically significant increases in serum creatinine concentration and urinary flow occurred in all three gentamicin-treated groups during the period of treatment. Anesthesia with either enflurane or halothane in rats with chronic renal impairment treated with gentamicin did not result in additional renal damage.
为评估对肾功能异常大鼠产生肾毒性的可能性，在六组每组六只Fischer 344大鼠中进行了研究，这些大鼠均通过手术诱导造成慢性肾功能损害，分别接受1个最低肺泡有效浓度（MAC）的恩氟烷或氟烷麻醉两小时。作为一个额外的诱发因素，在三组大鼠中，于麻醉前一周及麻醉后一周给予庆大霉素，剂量为5毫克/千克/天，其中一组用恩氟烷麻醉，一组用氟烷麻醉，一组不麻醉。肾功能的变化均不能归因于任何一种麻醉剂。恩氟烷麻醉后4小时和24小时，庆大霉素治疗组和未用庆大霉素治疗组的血清无机氟水平相似。在治疗期间，所有三个庆大霉素治疗组的血清肌酐浓度和尿流量均出现临床上虽小但具有统计学意义的升高。在接受庆大霉素治疗的慢性肾功能损害大鼠中，恩氟烷或氟烷麻醉均未导致额外的肾损伤。
