Sievenpiper T S, Rice S A, McClendon F, Kosek J C, Mazze R I
J Pharmacol Exp Ther. 1979 Oct;211(1):36-41.
Chronic renal insufficiency was produced surgically in Fischer 344 rats in order to evaluate the effects of enflurane anesthesia in animals with impaired renal function. Three groups of rats were anesthetized with enflurane: a control group without impairment of renal function (n = 7); a group with minimal impairment of renal function (n = 6); and a group with moderately severe renal impairment (n = 9). Another group of rats with moderately severe renal impairment (n = 8) was anesthetized with halothane. Two hours of anesthesia resulted only in mild transient depression of urea clearance in all groups. Six hours of anesthesia resulted in a 5 to 10 ml/day increase of urinary output in all groups and small increases in urea nitrogen levels in both groups with moderately severe renal impairment. Deterioration of the model was noted late in the experiment; at sacrifice, animals that had been anesthetized with enflurance and four with halothane had terminal renal failure. The morphological lesion in both groups was similar, resembling glomerulonephritis. Thus, there was no difference in the renal response to enflurane or halothane anesthesia among rats with chronic renal insufficiency.
为了评估恩氟烷麻醉对肾功能受损动物的影响，通过手术在Fischer 344大鼠中制造慢性肾功能不全。三组大鼠用恩氟烷麻醉：一组肾功能未受损的对照组（n = 7）；一组肾功能轻度受损的大鼠（n = 6）；以及一组肾功能中度严重受损的大鼠（n = 9）。另一组肾功能中度严重受损的大鼠（n = 8）用氟烷麻醉。两小时的麻醉仅导致所有组的尿素清除率出现轻度短暂下降。六小时的麻醉导致所有组的尿量每天增加5至10毫升，并且两组肾功能中度严重受损的大鼠的尿素氮水平均有小幅升高。在实验后期观察到模型恶化；在处死时，用恩氟烷麻醉的动物和四只用氟烷麻醉的动物出现终末期肾衰竭。两组的形态学病变相似，类似于肾小球肾炎。因此，慢性肾功能不全大鼠对恩氟烷或氟烷麻醉的肾脏反应没有差异。
