Halonen M, Palmer J D, Lohman I C, McManus L M, Pinckard R N
Am Rev Respir Dis. 1980 Dec;122(6):915-24. doi: 10.1164/arrd.1980.122.6.915.
We examined the physiologic alterations induced in the rabbit by an acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic compound identical to rabbit basophil-derived platelet-activating factor. Intravenous administration of AGEPC led to a brief period of rapid, shallow breathing, a transient apnea, a decrease in dynamic compliance, and an increase in total pulmonary resistance. Circulatory alterations included brief bradycardia, increase in right ventricular pressure, and systemic hypotension. At a dose of 0.6 microgram/kg, AGEPC produced physiologic alterations both qualitatively and quantitatively indistinguishable from those which characterize IgE anaphylaxis in the rabbit. Mortality was also similar. After recovery to prechallenge baseline values, subsequent doses of AGEPC resulted in attenuated responses with respect to many of the physiologic alterations. Thrombocytopenia, leukopenia, and platelet secretion (as assessed by release of platelet factor 4 into the plasma) were also part of the response to AGEPC, further extending the similarity of this response to IgE anaphylaxis. Because AGEPC has been shown previously to be released into the circulation during IgE anaphylaxis, our results provide strong evidence that AGEPC is an important mediator of this acute allergic reaction in the rabbit.
我们研究了乙酰甘油醚磷酸胆碱（AGEPC）对兔子诱导的生理改变，AGEPC是一种与兔嗜碱性粒细胞衍生的血小板活化因子相同的合成化合物。静脉注射AGEPC会导致一段短暂的快速、浅呼吸，短暂的呼吸暂停，动态顺应性降低，以及总肺阻力增加。循环系统改变包括短暂的心动过缓、右心室压力升高和全身性低血压。在剂量为0.6微克/千克时，AGEPC产生的生理改变在定性和定量上与兔子IgE过敏反应的特征无法区分。死亡率也相似。恢复到激发前的基线值后，后续剂量的AGEPC导致许多生理改变的反应减弱。血小板减少、白细胞减少和血小板分泌（通过血小板因子4释放到血浆中来评估）也是对AGEPC反应的一部分，进一步扩展了这种反应与IgE过敏反应的相似性。因为先前已证明在IgE过敏反应期间AGEPC会释放到循环中，我们的结果提供了强有力的证据，表明AGEPC是兔子这种急性过敏反应的重要介质。
