McManus L M, Pinckard R N, Fitzpatrick F A, O'Rourke R A, Crawford M H, Hanahan D J
Lab Invest. 1981 Oct;45(4):303-7.
The intravenous infusion of 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (AGEPC) in baboons (28 micrograms per kg.) induced acute, but reversible, thrombocytopenia and neutropenia and the intravascular release of platelet factor 4 and thromboxane B2. Maximal depression of circulating platelets and neutrophils occurred within 30 seconds after AGEPC infusion and was accompanied by significant elevations in plasma platelet factor 4 and thromboxane B2 levels (p less than 0.02). Hematocrit values increased after AGEPC infusion, but this increase was delayed relative to the other intravascular alterations, i.e., maximal hematocrit values occurred at 10 to 20 minutes after AGEPC infusion.. The thrombocytopenia induced by AGEPC was reversed within 2 to 3 minutes; in contrast, circulating neutrophils did not return to preinfusion levels until 30 minutes after AGEPC infusion. Plasma platelet factor 4 and thromboxane B2 elevations gradually decreased and returned to preinfusion levels within 30 to 60 minutes. The deacetylated derivative of AGEPC, lyso-glyceryl ether phosphorylcholine, had no effect when similarly infused into baboons. These studies demonstrate that the intravenous administration of AGEPC into baboons initiated significant but reversible intravascular alterations; thus, this unusual acetylated alkyl phosphoglyceride may be an important mediator of inflammation in primates, including man.
给狒狒静脉输注1-O-十六烷基/十八烷基-2-乙酰基-sn-甘油-3-磷酸胆碱（AGEPC）（每千克28微克）可引起急性但可逆的血小板减少和中性粒细胞减少，以及血小板因子4和血栓素B2的血管内释放。AGEPC输注后30秒内循环血小板和中性粒细胞出现最大程度的减少，并伴有血浆血小板因子4和血栓素B2水平显著升高（p<0.02）。AGEPC输注后血细胞比容值升高，但这种升高相对于其他血管内变化出现延迟，即AGEPC输注后10至20分钟出现最大血细胞比容值。AGEPC诱导的血小板减少在2至3分钟内逆转；相比之下，循环中性粒细胞直到AGEPC输注后30分钟才恢复到输注前水平。血浆血小板因子4和血栓素B2的升高逐渐下降，并在30至60分钟内恢复到输注前水平。AGEPC的去乙酰化衍生物溶血甘油醚磷酸胆碱以类似方式输注到狒狒体内时没有效果。这些研究表明，向狒狒静脉内给予AGEPC会引发显著但可逆的血管内变化；因此，这种不寻常的乙酰化烷基磷酸甘油酯可能是包括人类在内的灵长类动物炎症的重要介质。
