8-甲氧基补骨脂素加紫外线A（PUVA）对豚鼠全身诱导二硝基氯苯（DNCB）接触敏感性的抑制作用。

Inhibitory effect of 8-methoxysporalen plus UVA (PUVA) on the systemic induction of contact sensitivity to dinitrochlorobenzene (DNCB) in guinea pigs.

作者信息

Meyer J C, Grundmann H P, Weiss H

出版信息

Arch Dermatol Res. 1980;269(2):189-95. doi: 10.1007/BF00406539.

Abstract

To investigate the influence of 8-MOP and UVA on the induction of cell-mediated immunity, guinea pigs, sensitized with a single injection of dinitrofluorobenzene (DNFB) in Freund's complete adjuvant (FCA) in all footpads and the nuchal skin, were treated with 8-MOP, UVA, or 8-MOP + UVA on days 0, 2, and 5 and tested with dinitrochlorobenzene (DNCB) on day 14 after sensitization. Two control groups, exposed in a covered condition to the PUVA 4000 lamp, to observe the heat effect, showed a slightly enhanced contact sensitivity in comparison to the only sensitized control group. No altered reactivity was observed after irradiation with longwave UV light alone, whereas a statistically significant enhanced resp. reduced contact sensitivity was obtained after the treatment with 8-MOP alone and the combined action of 8-MOP + UVA, respectively.

摘要

为研究8-甲氧基补骨脂素（8-MOP）和紫外线A（UVA）对细胞介导免疫诱导的影响，将豚鼠在所有足垫和颈部皮肤中单次注射二硝基氟苯（DNFB）于弗氏完全佐剂（FCA）中进行致敏，在致敏后的第0、2和5天用8-MOP、UVA或8-MOP + UVA进行处理，并于致敏后第14天用二硝基氯苯（DNCB）进行检测。两个对照组在覆盖条件下暴露于PUVA 4000灯以观察热效应，与仅致敏的对照组相比，接触敏感性略有增强。单独用长波紫外线照射后未观察到反应性改变，而单独用8-MOP处理以及8-MOP + UVA联合作用后，分别获得了统计学上显著增强的或降低的接触敏感性。