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储存对兔骨骼肌AMP脱氨酶活性及亚基结构的影响。

Effects of storage on activity and subunit structure of rabbit skeletal-muscle AMP deaminase.

作者信息

Ranieri-Raggi M, Raggi A

出版信息

Biochem J. 1980 Aug 1;189(2):367-8. doi: 10.1042/bj1890367.

DOI:10.1042/bj1890367
PMID:7458918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1162007/
Abstract

On storage, AMP deaminase is converted into a form exhibiting hyperbolic kinetics even at low KCl concentration. This effect results from cleavage of the enzyme subunit (mol.wt. 79 000) to a product of similar size to the component of approx. mol.wt. 70 000 present in trace amounts in AMP deaminase just prepared from fresh muscle.

摘要

在储存过程中，即使在低氯化钾浓度下，AMP脱氨酶也会转化为呈现双曲线动力学的形式。这种效应是由于酶亚基（分子量79000）裂解为与刚从新鲜肌肉中制备的AMP脱氨酶中微量存在的约分子量70000的组分大小相似的产物所致。

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Effects of storage on activity and subunit structure of rabbit skeletal-muscle AMP deaminase.储存对兔骨骼肌AMP脱氨酶活性及亚基结构的影响。
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本文引用的文献

1
Ammonia liberation during rigor mortis and its relation to changes in the adenine and inosine nucleotides of rabbit muscle.尸僵期间氨的释放及其与兔肌肉中腺嘌呤和肌苷核苷酸变化的关系。
Biochim Biophys Acta. 1957 Oct;26(1):93-103. doi: 10.1016/0006-3002(57)90059-8.
2
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳测定分子量的可靠性。
J Biol Chem. 1969 Aug 25;244(16):4406-12.
3
Muscle AMP aminohydrolase. I. Some regulatory properties of rat skeletal muscle enzyme.肌肉AMP氨基水解酶。I. 大鼠骨骼肌酶的一些调节特性。
Biochim Biophys Acta. 1968 Nov 19;167(3):626-9. doi: 10.1016/0005-2744(68)90058-2.
4
An investigation of the subunit structure and AMP-deaminases from rabbit and chicken muscle.兔和鸡肌肉中AMP脱氨酶的亚基结构研究。
Biochem Biophys Res Commun. 1971 Nov;45(4):1025-32. doi: 10.1016/0006-291x(71)90440-2.
5
AMP deaminase from rabbit skeletal muscle: the effect of monovalent cations on catalytic activity and molecular weight.兔骨骼肌中的AMP脱氨酶：单价阳离子对催化活性和分子量的影响。
Biochim Biophys Acta. 1972 Feb 28;258(2):618-25. doi: 10.1016/0005-2744(72)90253-7.
6
Subunit sizes of muscle proteins, as determined by sodium dodecyl sulphate gel electrophoresis.通过十二烷基硫酸钠凝胶电泳测定的肌肉蛋白质亚基大小。
Biochim Biophys Acta. 1971 May 25;236(2):409-15. doi: 10.1016/0005-2795(71)90221-2.
7
Rat muscle 5'-adenylic acid aminohydrolase. I. Purification and subunit structure.大鼠肌肉5'-腺苷酸氨基水解酶。I. 纯化及亚基结构
J Biol Chem. 1975 Sep 10;250(17):6653-8.
8
Subunit structures of AMP deaminase isozymes in rat.大鼠中AMP脱氨酶同工酶的亚基结构
Biochem Biophys Res Commun. 1977 Dec 7;79(3):671-6. doi: 10.1016/0006-291x(77)91164-0.
9
Activation of AMP aminohydrolase during skeletal-muscle contraction.骨骼肌收缩过程中AMP氨基水解酶的激活。
Biochem J. 1979 Oct 15;184(1):173-6. doi: 10.1042/bj1840173.
10
Regulation of skeletal muscle AMP deaminase: effects of limited proteolysis on the activity of the rabbit enzyme.骨骼肌AMP脱氨酶的调节：有限蛋白水解对兔酶活性的影响。
FEBS Lett. 1979 Jun 1;102(1):59-63. doi: 10.1016/0014-5793(79)80928-x.