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骨骼肌收缩过程中AMP氨基水解酶的激活。

Activation of AMP aminohydrolase during skeletal-muscle contraction.

作者信息

Rahim Z H, Lutaya G, Griffiths J R

出版信息

Biochem J. 1979 Oct 15;184(1):173-6. doi: 10.1042/bj1840173.

Abstract

AMP aminohydrolase activity is enhanced by 60% after 5 s tetanic stimulation of phosphorylase kinase-deficient mouse muscle and after 60 s tetanus in normal mice. During the recovery from tetanus the activity in the contralateral leg is similarly enhanced. The activation is stable to 1000-fold dilution and has a half-life of approx. 1 h.

摘要

在对磷酸化酶激酶缺陷型小鼠肌肉进行5秒强直刺激后以及对正常小鼠进行60秒强直刺激后,AMP氨基水解酶活性增强了60%。在破伤风恢复过程中,对侧腿部的活性也同样增强。这种激活在稀释1000倍时仍保持稳定,半衰期约为1小时。

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Comparative enzymology of 5'-AMP aminohydrolase from normal and genetically dystrophic chicken muscle.
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本文引用的文献

6
Skeletal muscle purine nucleotide levels in normal and phosphorylase kinase deficient mice.
FEBS Lett. 1976 Oct 15;69(1):203-6. doi: 10.1016/0014-5793(76)80687-4.
8
The molecular basis of skeletal muscle phosphorylase kinase deficiency.
Eur J Biochem. 1976 Jul 1;66(2):347-56. doi: 10.1111/j.1432-1033.1976.tb10524.x.
10
Phosphorylase kinase isoenzymes in deficient ICR/IAn mice.
Eur J Biochem. 1978 Oct;90(2):369-75. doi: 10.1111/j.1432-1033.1978.tb12613.x.

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