胆汁酸对E玫瑰花结形成及植物血凝素刺激的影响。
Effect of bile acids on E rosette formation and PHA stimulation.
作者信息
Surrenti C, Casini A, Ramarli D
出版信息
Boll Ist Sieroter Milan. 1980 May 31;59(2):133-7.
PMID:7459018
Abstract
The effect of bile acids on E rosette formation and lymphocyte response to PHA was studied. Pooled conjugated and unconjugated bile acids decreased normal lymphocyte E rosette formation in vitro. This inhibition is related to bile acid concentration. Unconjugated bile acids induced a depression of PHA stimulation in comparison to controls. These findings suggest that bile acids can play a role in the depression of cellular immunity observed in patients with cholestasis.
摘要
研究了胆汁酸对E玫瑰花结形成及淋巴细胞对植物血凝素（PHA）反应的影响。混合的结合型和非结合型胆汁酸在体外可降低正常淋巴细胞的E玫瑰花结形成。这种抑制作用与胆汁酸浓度有关。与对照组相比，非结合型胆汁酸可导致PHA刺激反应降低。这些发现提示胆汁酸可能在胆汁淤积患者所观察到的细胞免疫抑制中起作用。
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