[舒必利异构体对人体血压控制的影响]
[Effects of sulpiride isomers in the control of blood pressure in man].
作者信息
Benfenati F, Cortelli P, de Camillis M, Orlandi F, Forni C
出版信息
Boll Soc Ital Biol Sper. 1980 Sep 15;56(17):1789-94.
The effects of d-Sulpiride (25 mg i.v.) and 1-Sulpiride (25 mg i.v.) administration in the control of arterial blood pressure (ABP) and PRL-GH secretion have been analyzed in five normal male volunteers. It was observed a quite different action on ABP, 1-Sulpiride causing a long lasting hypotension and d-Sulpiride a short-lived hypertension. The correlation between ABP, heart rate and PRL-GH levels suggests a probable central cation for 1-Sulpiride and a possible peripheral action for d-Sulpiride effects on ABP.
已对5名正常男性志愿者静脉注射25毫克右旋舒必利和25毫克左旋舒必利在控制动脉血压（ABP）及催乳素-生长激素（PRL-GH）分泌方面的作用进行了分析。观察到它们对ABP有截然不同的作用，左旋舒必利可导致持久的低血压，而右旋舒必利则引起短暂的高血压。ABP、心率与PRL-GH水平之间的相关性表明，左旋舒必利可能作用于中枢，而右旋舒必利对ABP的影响可能是外周作用。
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