Benfenati F, De Camillis E, Cortelli P, Orlandi F
Boll Soc Ital Biol Sper. 1980 Jun 30;56(12):1226-32.
The sterical requirements of dopamine (DA) receptors involved in the control of prolactin (PL) secretion have been analyzed by studying the effects of the administration of d- and l-sulpiride (25 mg i.v.) on PL serum levels in five normal male volunteers. Both d- and l-sulpiride cause a remarkable rise in PL serum levels, the only difference between the two drugs being the lower decay rate of hormone levels after the l-isomer. The results obtained are discussed in the frame of a possible low steric selectivity of DA receptors controlling PL secretion in the hyposthalamo-pituitary axis.
通过研究给予5名正常男性志愿者静脉注射25毫克d-和l-舒必利后对血清催乳素（PL）水平的影响，分析了参与催乳素分泌控制的多巴胺（DA）受体的空间需求。d-和l-舒必利均可导致血清PL水平显著升高，两种药物之间的唯一区别在于l-异构体给药后激素水平的衰减率较低。在控制下丘脑-垂体轴中PL分泌的DA受体可能存在低空间选择性的框架内，对所得结果进行了讨论。
