接受免疫治疗剂量环孢素A的大鼠的肝肾功能。
Hepatic and renal function in rats receiving immunotherapeutic doses of cyclosporin A.
作者信息
Whiting P H, Thomson A W, Cameron I D, Simpson J G
出版信息
Br J Exp Pathol. 1980 Dec;61(6):631-4.
Adult Sprague--Dawley rats were given either 25 or 50 mg/kg cyclosporin A (Cy A) orally every 48 h during the course of an immune response to sheep red blood cells (SRBC). A profound reduction in serum haemagglutinin titres was observed at 7 and 14 days only in animals given 50 mg. Apart from a small transient elevation in transaminase levels there were no serological indications of impaired hepatic or renal function at either dose of Cy A. There was also no increase in urinary NAG (N-acetyl-beta-D-glucosaminidase) levels, indicating the absence of damage to renal tubular cells. These observations are consistent with the normal histological and ultrastructural findings in liver and kidney in this study.
在对绵羊红细胞（SRBC）产生免疫反应的过程中，成年斯普拉格-道利大鼠每48小时口服25或50毫克/千克环孢素A（Cy A）。仅在给予50毫克剂量的动物中，观察到7天和14天时血清血凝素滴度显著降低。除转氨酶水平有小幅度短暂升高外，两种剂量的Cy A均未出现肝功能或肾功能受损的血清学指征。尿N-乙酰-β-D-氨基葡萄糖苷酶（NAG）水平也未升高，表明肾小管细胞未受损伤。这些观察结果与本研究中肝脏和肾脏正常的组织学和超微结构 findings相符。 （注：原文中“findings”未翻译完整，可能是遗漏了具体内容，这里按原样保留）
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