Borel J F
Immunology. 1976 Oct;31(4):631-41.
Cell-mediated cytolysis (CMC) was assayed in a system using spleen cells from mice (C57BL/6) sensitized with allogeneic tumour cells (DBA/2 mastocytoma P-815). Anti-inflammatory drugs, immunosuppressives, inhibitors of cell division and other agents were investigated for their capacity to inhibit CMC in three different ways. First, inhibition of CMC after in vitro addition of drug was observed with corticosteroids, some immunosuppressives and inhibitors of cell division. Secondly, suppression of CMC after a single drug administration to sensitized mice shortly before being killed was found with corticosteroids, several immunosuppressives and irradiation. Thirdly, prevention of development of CMC by repeated drug treatment (immunosuppressive schedule) was achieved with most immunosuppressives and cytostatic drugs. Non-steroidal anti-inflammatory drugs were inactive in these tests. Correlation of effects between the three procedures was very poor and it is suggested that various mechanisms may be involved in the different assays.
在一个系统中检测细胞介导的细胞溶解作用（CMC），该系统使用用同种异体肿瘤细胞（DBA/2肥大细胞瘤P-815）致敏的小鼠（C57BL/6）的脾细胞。研究了抗炎药、免疫抑制剂、细胞分裂抑制剂和其他药物以三种不同方式抑制CMC的能力。首先，观察到皮质类固醇、一些免疫抑制剂和细胞分裂抑制剂在体外添加药物后对CMC有抑制作用。其次，在用皮质类固醇、几种免疫抑制剂和辐射处理致敏小鼠后，在处死前不久单次给药可抑制CMC。第三，大多数免疫抑制剂和细胞抑制药物通过重复药物治疗（免疫抑制方案）可预防CMC的发展。非甾体抗炎药在这些试验中无活性。这三种方法之间的效应相关性很差，提示不同的检测方法可能涉及多种机制。
