Eichhorn H J
Br J Radiol. 1981 Feb;54(638):132-5. doi: 10.1259/0007-1285-54-638-132.
The biological effects of different fractionation schemes have been evaluated by the histological examination of bronchial carcinomas removed at operation or autopsy following radiotherapy. Radiation was given in daily, small fractions (200 cGy (rad)), large fractions (600 cGy (rad)) every fifth day, or a single high dose followed by daily low-dose treatment. The highest proportion of tumours free of viable cells was found in patients who had received small daily fractions in both operable and inoperable tumours. A hypothesis is put forward to explain this apparent change in radio-sensitivity with different fractionation schemes.
通过对放疗后手术切除或尸检获得的支气管癌进行组织学检查，评估了不同分割方案的生物学效应。放疗采用每日小剂量分割（200 厘戈瑞（拉德））、每五天一次大剂量分割（600 厘戈瑞（拉德）），或单次高剂量后每日低剂量治疗。在可手术和不可手术肿瘤患者中，接受每日小剂量分割的患者肿瘤中无存活细胞的比例最高。提出了一个假设来解释不同分割方案下这种明显的放射敏感性变化。
