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从吉田肝癌AH - 130分离出的线粒体内外膜的磷脂组成

Phospholipid composition of inner and outer mitochondrial membranes isolated from Yoshida hepatoma AH-130.

作者信息

Garcea R, Canuto R A, Gautero B, Biocca M, Feo F

出版信息

Cancer Lett. 1980 Dec;11(2):133-9. doi: 10.1016/0304-3835(80)90104-4.

DOI:10.1016/0304-3835(80)90104-4
PMID:7459841
Abstract

Outer and inner membranes isolated from hepatoma AH-130 and rat liver mitochondria were used to study phospholipid composition. The phosphatidylethanolamine content increased and that of phosphatidylcholine decreased in ;whole mitochondria and isolated membranes. The ratio between the 2 phospholipids increased 47% and 117% in the inner and outer membranes respectively. A small decrease of diphosphatidylglycerol also occurred in the hepatoma mitochondria inner membrane. In contrast to the results of previous work, no sphingomyelin was found in hepatoma mitochondria and isolated membranes.

摘要

从肝癌AH - 130和大鼠肝脏线粒体中分离出的外膜和内膜用于研究磷脂组成。在整个线粒体和分离出的膜中,磷脂酰乙醇胺含量增加而磷脂酰胆碱含量降低。这两种磷脂之间的比例在内膜和外膜中分别增加了47%和117%。肝癌线粒体内膜中的二磷脂酰甘油也有少量减少。与之前的研究结果相反,在肝癌线粒体和分离出的膜中未发现鞘磷脂。

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