光学活性2-(N-苄基-N-甲基氨基)乙基 2,6-二甲基-4-(间硝基苯基)-1,4-二氢吡啶-3,5-二甲酸甲酯（尼卡地平）的合成 - Suppr

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超能文献

Synthesis of optically active 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (Nicardipine).

作者信息

Shibanuma T, Iwanani M, Okuda K, Takenaka T, Murakami M

出版信息

Chem Pharm Bull (Tokyo). 1980 Sep;28(9):2809-12. doi: 10.1248/cpb.28.2809.

DOI:10.1248/cpb.28.2809

PMID:7460104

Abstract

摘要

相似文献

Synthesis of optically active 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (Nicardipine).光学活性2-(N-苄基-N-甲基氨基)乙基 2,6-二甲基-4-(间硝基苯基)-1,4-二氢吡啶-3,5-二甲酸甲酯（尼卡地平）的合成

Chem Pharm Bull (Tokyo). 1980 Sep;28(9):2809-12. doi: 10.1248/cpb.28.2809.

Application of the stable isotope technique to the elucidation of the saturation phenomenon of nicardipine hydrochloride metabolizing enzyme activity in dogs.稳定同位素技术在阐明犬体内盐酸尼卡地平代谢酶活性饱和现象中的应用。

Biomed Mass Spectrom. 1980 Aug;7(8):339-44. doi: 10.1002/bms.1200070805.

Comparative pharmacokinetics of nicardipine hydrochloride, a new vasodilator, in various species.新型血管扩张剂盐酸尼卡地平在不同物种中的比较药代动力学。

Xenobiotica. 1980 Jun;10(6):447-54. doi: 10.3109/00498258009033779.

Vasodilator profile of a new 1,4-dihydropyridine derivative, 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]-ethyl ester 5-methyl ester hydrochloride (YC-93).

Arzneimittelforschung. 1976;26(12):2172-8.

Effects of nicardipine, a new dihydropyridine vasodilator, on coronary circulation and ischemia-induced conduction delay in dogs.新型二氢吡啶类血管扩张剂尼卡地平对犬冠状动脉循环及缺血诱导的传导延迟的影响。

Arzneimittelforschung. 1982;32(6):626-9.

Inhibition of cyclic AMP phosphodiesterase by 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)] ethyl ester 5-methyl ester hydrochloride (YC-93), a potent vasodilator.强效血管扩张剂2,6 - 二甲基 - 4 - (3 - 硝基苯基) - 1,4 - 二氢吡啶 - 3,5 - 二羧酸3 - [2 - (N - 苄基 - N - 甲基氨基)]乙酯5 - 甲酯盐酸盐（YC - 93）对环磷酸腺苷磷酸二酯酶的抑制作用

Biochem Pharmacol. 1978;27(8):1269-74. doi: 10.1016/0006-2952(78)90462-8.

Determination of a new cerebral vasodilator 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]-ethyl ester 5-methyl ester hydrochloride (YC-93) in plasma by electron capture gas chromatography.采用电子捕获气相色谱法测定血浆中新型脑血管扩张剂2,6-二甲基-4-(3-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸3-[2-(N-苄基-N-甲基氨基)]-乙酯5-甲酯盐酸盐（YC-93）

J Chromatogr. 1975 Jul 16;110(2):301-7. doi: 10.1016/0021-9673(75)85010-2.

Specific determination of plasma nicardipine hydrochloride levels by gas chromatography-mass spectrometry.采用气相色谱-质谱联用法定量测定血浆中盐酸尼卡地平的含量。

J Chromatogr. 1981 May 8;223(2):341-9. doi: 10.1016/s0378-4347(00)80106-1.

Effect of TC-81, a new dihydropyridine derivative, on K(+)-induced contraction in rat aorta.新型二氢吡啶衍生物TC-81对大鼠主动脉钾离子诱导收缩的影响。

Eur J Pharmacol. 1991 Nov 19;205(1):49-54. doi: 10.1016/0014-2999(91)90769-m.

Vasodilating effects of the new calcium antagonist benidipine hydrochloride in anesthetized dogs and cats.新型钙拮抗剂盐酸贝尼地平对麻醉犬猫的血管舒张作用。

Arzneimittelforschung. 1988 Nov;38(11A):1707-12.

引用本文的文献

1,4-dihydropyridines: the multiple personalities of a blockbuster drug family.1,4 - 二氢吡啶类：一个畅销药物家族的多重特性

Transl Med UniSa. 2012 Oct 11;4:12-26. Print 2012 Sep.

Streptomyces serine protease (DHP-A) as a new biocatalyst capable of forming chiral intermediates of 1,4-dihydropyridine calcium antagonists.链霉菌丝氨酸蛋白酶（DHP-A）作为一种新型生物催化剂，能够形成1,4-二氢吡啶类钙拮抗剂的手性中间体。

Appl Environ Microbiol. 2002 Jun;68(6):2716-25. doi: 10.1128/AEM.68.6.2716-2725.2002.

Searching for balanced hybrid NO-donor 1,4-dihydropyridines with basic properties.

Pharm Res. 2001 Jul;18(7):987-91. doi: 10.1023/a:1010992412549.

Effects of unsymmetrical ester substituted 1,4-dihydropyridine derivatives and their optical isomers on contraction of smooth muscle.不对称酯取代的1,4-二氢吡啶衍生物及其光学异构体对平滑肌收缩的影响。

Naunyn Schmiedebergs Arch Pharmacol. 1981 Sep;317(2):183-5. doi: 10.1007/BF00500079.

Nicardipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in the treatment of angina pectoris, hypertension and related cardiovascular disorders.尼卡地平。对其治疗心绞痛、高血压及相关心血管疾病的药效学、药代动力学特性及治疗效果的综述。

Drugs. 1987 Apr;33(4):296-345. doi: 10.2165/00003495-198733040-00002.

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