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[渐进性延长对兔子的影响。实验研究(作者译)]

[Consequences of progressive lengthenings on rabbits. Experimental study (author's transl)].

作者信息

Pouliquen J C, Chaboche P, Pennecot G F, Bergue A

出版信息

Chir Pediatr. 1980;21(5):363-7.

PMID:7460118
Abstract

The authors performed 12 femur progressive lengthenings on rabbits during growth period. The lengthening was effected with a small distractor after a transversal bone section. The lengthening was 7,5 mm on 4 rabbits in 5 days (group 1) 10,5 mm on 4 rabbits in 7 days (groups 2), 15 mm on 4 rabbits in 10 days (group 3. At the end of the lengthening, the authors compared the non operated limb with arteris, veins, nerves, muscles and growth cartilage of the operated side. They found no modification of the muscular structure in the 3 groups. They substantieted few arterial and veinous modifications in group 1 and 2 the arteriel modifications were minimal but veinous modifications were important in group 3. The nervous anomalies wer evident in the 3 groups; the more important the lengthening, the more severe the anomalies; ranging from nerve ondulations in group 1, to vacuolar degenerscence and fibres ruptur in group 3. The authors studied the growth cartilage modificate at the furthest extremity from the femur by counting the cells in the various layers of the cartilage. They noted a significant descrease of the cell in the proliferative zone. This descrease might be due to a cartilage suffering. The modifications in the hypertrophic zone are less important, inconstant and result in a increase of the number of the cells. The authors think that the consequences of those important modifications on the nerve and on the growth cartilage are constant enough to complete this study by other lengthenings. This study coroborates their theory that all the consequences of a lengthening performed in a child are far from being perfectly known.

摘要

作者在生长期对12只兔子进行了股骨渐进性延长实验。在横向截骨后,使用小型撑开器进行延长。4只兔子在5天内延长7.5毫米(第1组),4只兔子在7天内延长10.5毫米(第2组),4只兔子在10天内延长15毫米(第3组)。延长结束时,作者将未手术侧肢体与手术侧的动脉、静脉、神经、肌肉和生长软骨进行了比较。他们发现3组中肌肉结构均无改变。他们证实第1组和第2组有少量动脉和静脉改变,第1组动脉改变最小,但第3组静脉改变明显。3组均有明显的神经异常;延长越严重,异常越严重;从第1组的神经波动到第3组的空泡变性和纤维断裂。作者通过计数软骨各层细胞,研究了股骨最远端的生长软骨变化。他们注意到增殖区细胞明显减少。这种减少可能是由于软骨受损。肥大区的变化不太重要,不恒定,导致细胞数量增加。作者认为,这些重要变化对神经和生长软骨的影响足够稳定,足以通过其他延长实验来完成这项研究。这项研究证实了他们的理论,即儿童延长手术的所有后果远未完全清楚。

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