Dorr R T, Alberts D S, Chen H S
Cancer Chemother Pharmacol. 1980;5(1):17-20. doi: 10.1007/BF00578557.
Local skin necrosis is a serious complication of doxorubicin (Adriamycin) infiltration in man. Intradermal (ID) doxorubicin infection was used in the mouse to create skin lesions, after which a number of local corticosteroid interventions were studied. The most effective local antidote was low-dose (2.5 mg) hydrocortisone (HC), but only against the low-dose doxorubicin challenge (0.05 mg). Other andidotes with lesser effectiveness included dexamethasone-sodium bicarbonate and an intermediate dose of HC (6.25 mg). Larger doses of ID HC did not prevent local doxorubicin toxicity and were inherently toxic to the skin. Systemic corticosteroids were similarly ineffective. The superiority of the low ID HC dose, the ineffectiveness of additions (sodium bicarbonate, topical HC cream), and the resistance of the high-dose doxorubicin ID challenge (0.5 mg) suggests a limited role for corticosteroids in the management of experimental doxorubicin skin toxicity.
局部皮肤坏死是阿霉素（阿霉素）渗入人体后的一种严重并发症。在小鼠中使用皮内（ID）阿霉素感染来造成皮肤损伤，之后研究了多种局部皮质类固醇干预措施。最有效的局部解毒剂是低剂量（2.5毫克）氢化可的松（HC），但仅针对低剂量阿霉素挑战（0.05毫克）。其他效果较差的解毒剂包括地塞米松 - 碳酸氢钠和中等剂量的HC（6.25毫克）。更大剂量的ID HC并不能预防局部阿霉素毒性，且本身对皮肤有毒性。全身用皮质类固醇同样无效。低ID HC剂量的优越性、添加物（碳酸氢钠、局部HC乳膏）的无效性以及高剂量阿霉素ID挑战（0.5毫克）的抗性表明皮质类固醇在实验性阿霉素皮肤毒性管理中的作用有限。
