Gallagher J S, Splansky G L, Bernstein I L
Clin Allergy. 1980 Nov;10(6):683-90. doi: 10.1111/j.1365-2222.1980.tb02152.x.
The effect of tartrazine (T) (yellow dye No. 5) and one of its metabolites an aminopyrazolone analogue (1-sulphophenyl-3-carboxy-5-hydroxypyrazole, SCHP) upon collagen-induced platelet aggregation (C-PA) was investigated in fourteen atopic patients and fourteen normal subjects. Both T and SCHP inhibited C-PA in atopic patients at significantly lower doses than in normal volunteers. The mean inhibitory concentrations of SCHP were similar to aspirin in both atopic and normal individuals. Although the precise mechanism by which these chemicals block C-PA has not been elucidated, this in vitro system may be a useful method of assessing non-immune mechanisms involved in reactions to tartrazine.
在14名特应性患者和14名正常受试者中，研究了酒石黄（T）（黄色素5号）及其一种代谢产物氨基吡唑啉类似物（1-磺基苯基-3-羧基-5-羟基吡唑，SCHP）对胶原诱导的血小板聚集（C-PA）的影响。与正常志愿者相比，T和SCHP在特应性患者中抑制C-PA所需的剂量显著更低。在特应性个体和正常个体中，SCHP的平均抑制浓度与阿司匹林相似。尽管这些化学物质阻断C-PA的确切机制尚未阐明，但该体外系统可能是评估酒石黄反应中涉及的非免疫机制的一种有用方法。
