Grzelewska-Rzymowska I, Szmidt M, Kowalski M L, Roźniecki J
Allergol Immunopathol (Madr). 1986 Jan-Feb;14(1):31-6.
The occurrence of sensitivity to tartrazine was examined in 51 patients with asthma and aspirin sensitivity. All patients underwent oral challenge tests with aspirin and tartrazine. Sensitivity to tartrazine was found in 16 i.e. 31.4% of tested asthmatics. The symptoms of sensitivity to tartrazine were similar to those of aspirin. Tolerance to tartrazine was induced in 5 aspirin and tartrazine sensitive asthmatics. Sensitivity to both substances was manifested in these 5 persons as dyspnea but 2 of them had additional extrabronchial symptoms. A good tolerance of 40 mg tartrazine was achieved in all the challenged patients who did not refer any dyspnea and extrabronchial symptoms. It was also proven that, being in the aspirin tolerance state the patients could be given tartrazine with no sensitivity symptoms. The authors think that the possibility of inducing tartrazine and aspirin tolerance, as well as the course of sensitivity reaction to both substances, both point to a similar pathogenetic background.
对51例哮喘且对阿司匹林敏感的患者进行了酒石黄敏感性的研究。所有患者均接受了阿司匹林和酒石黄的口服激发试验。在16例（即31.4%的受试哮喘患者）中发现了对酒石黄的敏感性。对酒石黄敏感的症状与对阿司匹林敏感的症状相似。在5例对阿司匹林和酒石黄敏感的哮喘患者中诱导出了对酒石黄的耐受性。这5例患者对两种物质的敏感性均表现为呼吸困难，但其中2例还有其他支气管外症状。所有接受激发试验且未出现任何呼吸困难和支气管外症状的患者对40毫克酒石黄均有良好的耐受性。还证实，处于阿司匹林耐受状态的患者服用酒石黄时不会出现敏感症状。作者认为，诱导酒石黄和阿司匹林耐受性的可能性以及对两种物质敏感反应的过程均表明存在相似的发病机制背景。
