人中枢神经系统肿瘤中二氢叶酸还原酶的鉴定
Identification of dihydrofolate reductase in human central-nervous-system tumours.
作者信息
Abelson H T, Fosburg M, Gorka C, Kornblith P
出版信息
Lancet. 1978 Jan 28;1(8057):184-5. doi: 10.1016/s0140-6736(78)90615-3.
PMID:74608
Abstract
Ten primary and two metastatic central-nervous system (C.N.S.) tumours were assayed. They all contained dihydrofolate reductase. This finding provides a biochemical rationale for antifolate therapy of C.N.S. tumours by methotrexate.
摘要
对10例原发性和2例转移性中枢神经系统（C.N.S.）肿瘤进行了检测。它们均含有二氢叶酸还原酶。这一发现为用甲氨蝶呤对C.N.S.肿瘤进行抗叶酸治疗提供了生化依据。
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