Villasante A, de la Torre J, Manso-Martínez R, Avila J
Eur J Biochem. 1980 Dec;112(3):611-6. doi: 10.1111/j.1432-1033.1980.tb06126.x.
Addition of DNA to microtubule protein solutions results in a decrease of the amount of the high-molecular-weight microtubule-associated proteins (MAP1 and MAP2) available for polymerization. Complete removal of MAP1 from microtubules requires lower concentrations of DNA compared to MAP2. Removal of MAP1 from microtubules has little or no effect on microtubule polymerization (nucleation and propagation). In contrast, removal of MAP2 produces a marked decrease in microtubule polymerization. Incubation of microtubular protein with DNA results in complete disappearance of the 30-S ring-shaped oligomers at concentrations of DNA which are not markedly inhibitory of polymerization.
向微管蛋白溶液中添加DNA会导致可用于聚合的高分子量微管相关蛋白（MAP1和MAP2）的量减少。与MAP2相比，从微管中完全去除MAP1所需的DNA浓度更低。从微管中去除MAP1对微管聚合（成核和延伸）几乎没有影响。相反，去除MAP2会使微管聚合显著减少。在DNA浓度对聚合没有明显抑制作用的情况下，微管蛋白与DNA一起温育会导致30-S环形寡聚物完全消失。
