吸烟与工业污染及其对更年期和卵巢癌的影响。
Smoking and industrial pollution, and their effects on menopause and ovarian cancer.
作者信息
Mattison D R, Thorgeirsson S S
出版信息
Lancet. 1978 Jan 28;1(8057):187-8. doi: 10.1016/s0140-6736(78)90617-7.
PMID:74610
Abstract
The rodent ovary contains an enzyme system(s) capable of metabolising poly-cyclic aromatic hydrocarbons to reactive electrophilic intermediates known to cause cytotoxicity, mutation, and cancer. If the human ovary contains similar enzyme systems, metabolic activation of environmental chemicals could explain the earlier menopause in cigarette smokers and the higher incidence of ovarian cancer in industrialised areas.
摘要
啮齿动物的卵巢含有一种酶系统，能够将多环芳烃代谢为具有细胞毒性、致突变性和致癌性的活性亲电中间体。如果人类卵巢含有类似的酶系统，环境化学物质的代谢活化就可以解释吸烟者绝经提前以及工业化地区卵巢癌发病率较高的现象。
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