Katz R J, Doyle R L
Eur J Pharmacol. 1980 Oct 17;67(2-3):301-3. doi: 10.1016/0014-2999(80)90512-9.
Adult male mice of the C57Bl/6J strain, or mice differing at a single locus from the above, pallid mice (C57Bl/6J-pa), were treated with morphine or vehicle and two responses associated with opiate receptor stimulation were examined. In comparison with vehicle treatment, morphine produced stereotyped running and reduced core temperature in the parent C57Bl/6J line. These responses were significantly enhanced in the coisogenic pallid line. Thus, a single gene may enhance normal sensitivity to opiates. This suggests the existence of discrete and identified biochemical influences upon sensitivity to opiates through genetic means, and offers a novel model of naturally occurring permanently altered opiate sensitivity.
选用C57Bl/6J品系的成年雄性小鼠，或与上述小鼠仅在一个基因座上存在差异的小鼠，即苍白小鼠（C57Bl/6J-pa），用吗啡或赋形剂进行处理，并检测与阿片受体刺激相关的两种反应。与赋形剂处理相比，吗啡在亲代C57Bl/6J品系中产生了刻板运动并降低了核心体温。在同基因苍白品系中，这些反应显著增强。因此，单个基因可能会增强对阿片类药物的正常敏感性。这表明通过遗传手段对阿片类药物敏感性存在离散且已确定的生化影响，并提供了一种自然发生的永久性改变阿片类药物敏感性的新模型。
