Shifrine M, Taylor N, Rosenblatt L S, Wilson F
Exp Hematol. 1980 Mar;8(3):318-26.
A whole blood lectin-induced lymphocyte stimulation test, using Con A and PHA, was used to assess the cell mediated immune status of 52 beagle dogs over a period of 16 months. The data indicated the presence of a seasonal variation in immune response with the peak estimated to be in July and an estimated trough in January. The relative amplitudes around the mean, for the two mitogens, were about 50%, so that the responses on lymphocyte division ranged from 50 to 150% of the mean during the course of the year. The possible implications of this finding for human health are discussed.
采用伴刀豆球蛋白A（Con A）和植物血凝素（PHA）进行全血凝集素诱导的淋巴细胞刺激试验，对52只比格犬在16个月的时间里的细胞介导免疫状态进行评估。数据表明免疫反应存在季节性变化，估计峰值在7月，低谷在1月。两种有丝分裂原围绕平均值的相对波动幅度约为50%，因此在一年中淋巴细胞分裂反应范围为平均值的50%至150%。本文讨论了这一发现对人类健康可能产生的影响。
