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相似文献

1
Biological rhythm of cell-mediated immunity in man.人类细胞介导免疫的生物节律。
Clin Exp Immunol. 1976 Nov;26(2):253-7.
2
Circadian rhythmicity of human plasma cortisol and PHA-induced lymphocyte transformation.人血浆皮质醇的昼夜节律性与PHA诱导的淋巴细胞转化
Clin Exp Immunol. 1975 Oct;22(1):190-3.
3
Effect of anaesthesia and surgery on the number of and mitogen-induced transformation of T- and B-lymphocytes.麻醉和手术对T淋巴细胞和B淋巴细胞数量及丝裂原诱导转化的影响。
Ann Clin Res. 1978 Feb;10(1):1-13.
4
Lymphocyte transformation by phytohaemagglutinin (PHA) and purified protein derivative (PPD) in primary biliary cirrhosis. Evidence of serum inhibitory factors.原发性胆汁性肝硬化中植物血凝素（PHA）和纯化蛋白衍生物（PPD）诱导的淋巴细胞转化。血清抑制因子的证据。
Clin Exp Immunol. 1973 Dec;15(4):523-33.
5
Immunosuppression by sex steroid hormones. The effect upon PHA- and PPD-stimulated lymphocytes.性甾体激素的免疫抑制作用。对PHA和PPD刺激淋巴细胞的影响。
Clin Exp Immunol. 1977 Mar;27(3):407-15.
6
In vitro lymphocyte stimulation in patients with lepromatous and borderline tuberculoid leprosy. The effect of dapsone treatment on the response to Mycobacterium leprae antigens, tuberculin purified protein derivative and non-mycobacterial stimulants.瘤型和界线类偏结核样型麻风患者的体外淋巴细胞刺激。氨苯砜治疗对麻风分枝杆菌抗原、结核菌素纯蛋白衍生物及非分枝杆菌刺激物反应的影响。
Int J Lepr Other Mycobact Dis. 1982 Dec;50(4):455-67.
7
Impaired lymphocyte transformation after accidental trauma.意外创伤后淋巴细胞转化受损。
Acta Chir Scand. 1979;145(6):367-72.
8
[Circadian rhythm of human lymphocyte subpopulations].[人类淋巴细胞亚群的昼夜节律]
Quad Sclavo Diagn. 1988 Jan-Dec;24(1-4):89-95.
9
Cellular and humoral immunity to purified protein derivative (PPD) in PPD skin reactive and nonreactive patients with pulmonary tuberculosis: comparative analysis of antigen-specific lymphocyte proliferation and IgG antibodies.肺结核患者中对纯化蛋白衍生物（PPD）皮肤反应阳性和阴性患者的细胞免疫和体液免疫：抗原特异性淋巴细胞增殖和IgG抗体的比较分析
Croat Med J. 2002 Jun;43(3):301-5.
10
Circadian changes of T lymphocyte subsets in human peripheral blood.人类外周血中T淋巴细胞亚群的昼夜变化。
Clin Exp Immunol. 1984 Mar;55(3):618-22.

引用本文的文献

1
Basal salivary cortisol secretion and susceptibility to upper respiratory infection.基础唾液皮质醇分泌与上呼吸道感染易感性
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2
Daily and seasonal rhythms in immune responses of splenocytes in the freshwater snake, Natrix piscator.淡水蛇渔游蛇脾脏细胞免疫反应的每日和季节性节律。
PLoS One. 2015 Feb 27;10(2):e0116588. doi: 10.1371/journal.pone.0116588. eCollection 2015.
3
Circadian changes of T lymphocyte subsets in human peripheral blood.人类外周血中T淋巴细胞亚群的昼夜变化。
Clin Exp Immunol. 1984 Mar;55(3):618-22.
4
Lymphocytes are rhythmic: is this important?淋巴细胞具有节律性：这重要吗？
Br Med J (Clin Res Ed). 1984 Nov 17;289(6455):1328-30. doi: 10.1136/bmj.289.6455.1328.
5
Seasonal modulation of the circadian time structure of circulating T and natural killer lymphocyte subsets from healthy subjects.健康受试者循环T淋巴细胞和自然杀伤淋巴细胞亚群昼夜时间结构的季节性调节。
J Clin Invest. 1988 Feb;81(2):407-13. doi: 10.1172/JCI113333.
6
Pharmacokinetics and pharmacodynamics of methylprednisolone when administered at 8 am versus 4 pm.上午8点与下午4点给药时甲泼尼龙的药代动力学和药效学。
Clin Pharmacol Ther. 1992 Jun;51(6):677-88. doi: 10.1038/clpt.1992.80.
7
The effects of biofeedback-assisted relaxation on cell-mediated immunity, cortisol, and white blood cell count in healthy adult subjects.生物反馈辅助放松对健康成年受试者细胞介导免疫、皮质醇和白细胞计数的影响。
J Behav Med. 1992 Aug;15(4):343-54. doi: 10.1007/BF00844727.
8
Sequential immunological studies on an asbestos-exposed population. I. Factors affecting peripheral blood leucocytes and T lymphocytes.石棉暴露人群的系列免疫学研究。I. 影响外周血白细胞和T淋巴细胞的因素。
Clin Exp Immunol. 1979 Nov;38(2):323-31.

本文引用的文献

1
A SIMPLE METHOD FOR IMPROVING THE SPECIFICITY OF THE FLUORIMETRIC DETERMINATION OF ADRENAL CORTICOSTEROIDS IN HUMAN PLASMA.一种提高人血浆中肾上腺皮质类固醇荧光测定特异性的简单方法。
J Endocrinol. 1965 Feb;31:235-44. doi: 10.1677/joe.0.0310235.
2
Human lymphocyte subpopulations. Effect of corticosteroids.人类淋巴细胞亚群。皮质类固醇的作用。
J Clin Invest. 1974 Feb;53(2):565-71. doi: 10.1172/JCI107591.
3
Corticosteroids and lymphoid cells.皮质类固醇与淋巴细胞。
N Engl J Med. 1972 Aug 24;287(8):388-97. doi: 10.1056/NEJM197208242870806.
4
The effect of in vivo hydrocortisone on subpopulations of human lymphocytes.体内氢化可的松对人淋巴细胞亚群的影响。
J Clin Invest. 1974 Jan;53(1):240-6. doi: 10.1172/JCI107544.
5
The effect of hydrocortisone on the incorporation of tritiated thymidine by human blood lymphocytes cultured with phytohaemagglutinin and pokeweed mitogen.氢化可的松对用植物血凝素和商陆有丝分裂原培养的人血淋巴细胞掺入氚标记胸腺嘧啶核苷的影响。
Clin Exp Immunol. 1973 Oct;15(2):203-12.
6
Serum and lymphocyte activation by phytohaemagglutinin (PHA).
Exp Cell Res. 1973 Mar 15;77(1):216-22. doi: 10.1016/0014-4827(73)90570-3.
7
A new micromethod for evaluating lymphocyte responses to phytohemagglutinin: quantitative analysis of the function of thymus-dependent cells.一种评估淋巴细胞对植物血凝素反应的新微量方法：胸腺依赖性细胞功能的定量分析。
Proc Natl Acad Sci U S A. 1972 Feb;69(2):371-3. doi: 10.1073/pnas.69.2.371.
8
Cell-mediated and humoral immune responses or renal transplant recipients with cytomegalovirus infections.细胞介导和体液免疫反应或患有巨细胞病毒感染的肾移植受者。
Clin Exp Immunol. 1974 Apr;16(4):565-73.
9
Potentation by fluorodeoxyuridine of 125I-deoxyuridine uptake by human and chicken lymphocytes in the quantitation of mitogenic response.在有丝分裂原反应定量中，氟脱氧尿苷对人和鸡淋巴细胞摄取¹²⁵I-脱氧尿苷的增强作用。
J Immunol Methods. 1974 Dec;6(1-2):73-82. doi: 10.1016/0022-1759(74)90091-x.
10
Circadian rhythmicity of human plasma cortisol and PHA-induced lymphocyte transformation.人血浆皮质醇的昼夜节律性与PHA诱导的淋巴细胞转化
Clin Exp Immunol. 1975 Oct;22(1):190-3.

人类细胞介导免疫的生物节律。

Biological rhythm of cell-mediated immunity in man.

作者信息

Eskola J, Frey H, Molnár G, Soppi E

出版信息

Clin Exp Immunol. 1976 Nov;26(2):253-7.

PMID:1033049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1540849/
Abstract

The biological rhythm of the spontaneous lymphocyte transformation and the lymphocyte response to phytohaemagglutinin (PHA), concanavalin A (Con A) and purified protein derivative of tuberculin (PPD) was studied in six healthy male volunteers. The count of peripheral blood lymphocytes was increasing from 08.00 until 02.00 hr. The level of plasma cortisol was highest at 08.00 hr and lowest at 20.00 hr. The spontaneous lymphocyte transformation showed a biphasic cycle during the day; the peak values were observed at 08.00 and 20.00 hr and a significant depression was found at 14.00 hr. The response of peripheral blood lymphocytes to PHA and Con A varied inversely with the level of plasma cortisol. The PPD response was lowest at 08.00 hr, but the highest value was observed at 02.00 hr. No significant day to day variation was found in any of the parameters studied.

摘要

在六名健康男性志愿者中研究了自发淋巴细胞转化以及淋巴细胞对植物血凝素（PHA）、刀豆蛋白A（Con A）和结核菌素纯蛋白衍生物（PPD）反应的生物节律。外周血淋巴细胞计数从08:00到02:00时呈上升趋势。血浆皮质醇水平在08:00时最高，在20:00时最低。自发淋巴细胞转化在白天呈现双相周期；峰值出现在08:00和20:00时，而在14:00时则出现显著下降。外周血淋巴细胞对PHA和Con A的反应与血浆皮质醇水平呈负相关。PPD反应在08:00时最低，但在02:00时观察到最高值。在所研究的任何参数中均未发现显著的每日变化。