小鼠骨髓中晚期红系祖细胞的细胞周期特性与增殖动力学
Cell-cycle properties and proliferation kinetics of late erythroid progenitors in murine bone marrow.
作者信息
Monette F C, Kent R B, Weiner E J, Jarris R F, Ouellette P L, Thorson J A, Zelick R D
出版信息
Exp Hematol. 1980 Apr;8(4):484-93.
The cell-cycle properties of marrow CFUE were assessed in normal regenerating cell preparations. In addition, the erythropoietin sensitivity of CFUE was correlated to the cell-cycle distribution of these cells. The results suggest a coupling of erythropoietin sensitivity to the S-phase of the CFUE cell cycle in so far as CFUE in G2/M/G1 were 2 to 10 times less sensitive to the hormone. It is concluded that the CFUE cell cycle per se is not a focus for erythropoietic regulation.
在正常再生细胞制剂中评估了骨髓CFUE的细胞周期特性。此外，CFUE对促红细胞生成素的敏感性与这些细胞的细胞周期分布相关。结果表明，促红细胞生成素敏感性与CFUE细胞周期的S期存在耦合关系，因为处于G2/M/G1期的CFUE对该激素的敏感性低2至10倍。得出的结论是，CFUE细胞周期本身并非红细胞生成调节的重点。
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