Meberg A
Exp Hematol. 1980 May;8(5):615-9.
Plasma erythropoietin (Ep) activity was detectable in fetal rats near term and in rats less than 2 old. Ep activity was not found 12--48 h after birth. A hypoxic period (0.5 atmospheres for 6 h) increased the plasma Ep level in fetal and newborn rats, and in pregnant animals. After long-term hypoxia (0.5 atmospheres for 8 days) the plasma Ep level was neither increased in fetal rats nor in their mothers, while a compensatory increase in the hematocrit level occurred. It is concluded that hypoxia stimulates Ep production during hepatic erythropoiesis. During long-term hypoxia compensatory mechanisms for tissue oxygenation occur.
在接近足月的胎鼠和2日龄以内的幼鼠体内可检测到血浆促红细胞生成素（Ep）活性。出生后12 - 48小时未发现Ep活性。缺氧期（0.5个大气压，持续6小时）可使胎鼠、新生鼠及孕鼠的血浆Ep水平升高。长期缺氧（0.5个大气压，持续8天）后，胎鼠及其母鼠的血浆Ep水平均未升高，而血细胞比容水平出现代偿性升高。结论是，缺氧在肝脏红细胞生成过程中刺激Ep产生。在长期缺氧期间，会出现组织氧合的代偿机制。
