Gaudenz R
Fortschr Med. 1980 Sep 25;98(36):1387-90.
The effect of intravenous Pg F2 alpha on the detrusor muscle in young healthy females during filling cystometry and during a long period of pressure normalization was studied. It was possible to induce uninhibited detrusor contractions in two thirds of the cases, very much resembling those of patients with motor-urge-incontinence. The sensitivity of the uterus was found to be higher than that of the bladder. Both organs responded with a gradual tone increase followed by regular contractions of the uterus and more erratic contractions of the detrusor. Therapeutic studies with a Pg-synthesis inhibitor (Indometacin) were undertaken with moderate success.
研究了静脉注射前列腺素F2α对年轻健康女性在膀胱充盈测压期间及长时间压力恢复正常过程中逼尿肌的影响。在三分之二的病例中可诱发逼尿肌无抑制性收缩，与运动性急迫性尿失禁患者的收缩非常相似。发现子宫的敏感性高于膀胱。两个器官均表现为张力逐渐增加，随后子宫出现规律性收缩，逼尿肌收缩则更不规则。使用前列腺素合成抑制剂（吲哚美辛）进行的治疗研究取得了一定成功。
