Jensen D
Acta Neurol Scand. 1981 Sep;64(3):145-74.
The influence on the cystometrogram of repeated filling and varying filling rates was studied in two groups of neurological patients, one with normal and one with uninhibited neurogenic bladder. A technique which permits an even bladder filling and a continuous recording of the intravesical pressure was used. The effect of repeated bladder filling without interval at a rate of 50 ml per min resulted in the following findings: In the normal bladder the intravesical pressure decreased at the second filling in three of the five patients. The bladder capacity remained unchanged in four of the five patients. In the uninhibited bladder, only a slight tendency to pressure decrease could be observed at the second filling in the 14 patients studied. The bladder capacity increased significantly (14 patients), while the amplitude of the uninhibited contraction was reduced (17 patients). These changes of the cystometric parameters cold be avoided in both groups when an interval of 20 min was interposed between the fillings. Varying filling rates (range 10 to 90 ml per min) resulted in the following findings: The normal bladder responded to higher filling rates partly with pressure increase (3 out of 6 patients), partly with pressure decrease (2 patients) or with unchanged pressure (1 patient). The capacity was independent of the filling rate. In the uninhibited neurogenic bladder, the pressure response to higher filling rates was either unchanged (11 out of 16 patients), higher pressure (3 patients) or a reduced pressure (2 patients). The capacity of the uninhibited bladder was not influenced by the filling rate in 10 out of 16 patients. The capacity increased at higher filling rates in four patients, and decreased in one. The amplitude of the uninhibited detrusor contraction was not influenced by the filling rate in nine out of 18 patients. The amplitude increased in five and decreased in four patients at higher filling rates. The present results show that an interval of at least 20 min has to be interposed between the fillings when cystometry with high and non-physiological filling rates is used for pharmacological studies. Otherwise, non-specific results will frequently be obtained. The influence of the rate of filling is of less importance as long as one and the same rate is used in the same experiments.
在两组神经科患者中研究了重复充盈及不同充盈速率对膀胱压力图的影响，一组患者膀胱功能正常，另一组患者为无抑制性神经源性膀胱。采用了一种能使膀胱均匀充盈并持续记录膀胱内压力的技术。以每分钟50毫升的速率不间断地重复膀胱充盈产生了以下结果：在正常膀胱中，五名患者中有三名在第二次充盈时膀胱内压力下降。五名患者中有四名膀胱容量保持不变。在无抑制性膀胱中，在所研究的14名患者中，仅在第二次充盈时观察到轻微的压力下降趋势。膀胱容量显著增加（14名患者），而无抑制性收缩的幅度减小（17名患者）。当两次充盈之间间隔20分钟时，两组患者的这些膀胱测压参数变化均可避免。不同的充盈速率（范围为每分钟10至90毫升）产生了以下结果：正常膀胱对较高的充盈速率部分表现为压力升高（6名患者中的3名），部分表现为压力下降（2名患者）或压力不变（1名患者）。容量与充盈速率无关。在无抑制性神经源性膀胱中，对较高充盈速率的压力反应要么不变（16名患者中的11名），要么压力升高（3名患者），要么压力降低（2名患者）。16名患者中有10名患者的无抑制性膀胱容量不受充盈速率影响。四名患者在较高充盈速率下容量增加，一名患者容量减少。18名患者中有9名患者的无抑制性逼尿肌收缩幅度不受充盈速率影响。在较高充盈速率下，五名患者的幅度增加，四名患者的幅度减小。目前的结果表明，当在药理学研究中使用高且非生理性充盈速率进行膀胱测压时，两次充盈之间必须间隔至少20分钟。否则，经常会得到非特异性结果。只要在同一实验中使用相同的速率，充盈速率的影响就不那么重要。
