Sievers U, von Kobyletzki D, Primavesi C A
Fortschr Med. 1980 Nov 13;98(42):1667-70.
Applicability, effect and toleration of dibekacin (Orbicin) were tested in pharmacokinetic, clinical and bacteriological studies treating 29 patients with severe surgical illnesses and 10 healthy volunteers as control group. The pharmacokinetic test results and the efficacy with severe infections showed dibekacin to be equivalent to the new aminoglycoside antibiotics gentamycin, sisomicin and tobramycin. Resistance was sporadic and severe side effects did not occur. Dibekacin proved itself to be a new alternative when aminoglycoside antibiotics are indicated
在一项药代动力学、临床和细菌学研究中，对29例患有严重外科疾病的患者和10名健康志愿者作为对照组进行了双去氧卡那霉素（奥贝星）的适用性、效果和耐受性测试。药代动力学测试结果以及对严重感染的疗效表明，双去氧卡那霉素等同于新的氨基糖苷类抗生素庆大霉素、西索米星和妥布霉素。耐药情况为散发性，且未出现严重副作用。当需要使用氨基糖苷类抗生素时，双去氧卡那霉素证明了自身是一种新的选择。
