Alpern M, Krantz D H
Invest Ophthalmol Vis Sci. 1981 Feb;20(2):183-203.
In four patients with abnormalities of the interface between photoreceptors and their vascular supply, bleached visual pigments regenerated abnormally slowly, with double exponential time courses, although the time constant of the first exponential was abnormally fast. During therapy in one patient the slower exponential returned to normal early after treatment, whereas the fast component persisted even after clinically complete recovery. The results could be explained by the following hypothesis. In normal eyes, two pigment-regeneration routes exist, the more rapid (which depends on a short-lived intermediate) playing no role after a long full bleach. Uvea abnormalities cause slower regeneration in the normal main route and slower breakdown of the normally short-lived intermediate.
在4例光感受器与其血管供应之间界面存在异常的患者中，漂白后的视觉色素再生异常缓慢，呈双指数时间进程，尽管第一个指数的时间常数异常快。在1例患者的治疗过程中，较慢的指数在治疗后早期恢复正常，而快速成分即使在临床完全恢复后仍持续存在。结果可由以下假设解释。在正常眼睛中，存在两条色素再生途径，较快的途径（依赖于一种短暂存在的中间体）在长时间完全漂白后不起作用。葡萄膜异常导致正常主要途径中的再生减慢，以及正常短暂存在的中间体的分解减慢。
