Holly F J, Lamberts D W
Invest Ophthalmol Vis Sci. 1981 Feb;20(2):236-45.
We found that the original osmolality of the tear film is regained rapidly subsequent to the installation of hypotonic artificial tears or other nonisotonic solutions. The minor irritation due to nonisotonicity and the increased tear volume both contribute to the increased turnover rate which in turn results in the short half-life (measured in seconds) of these solutions in the eye. Despite the expected fluctuation in tear volume and probably in tear secretion rate during the experiment, the osmolality of the tears followed an exponential decay with relatively good correlation.
我们发现，在滴入低渗人工泪液或其他非等渗溶液后，泪膜的初始渗透压会迅速恢复。非等渗性引起的轻微刺激以及泪液量增加，都导致了周转率的提高，这反过来又导致这些溶液在眼中的半衰期很短（以秒为单位）。尽管在实验过程中泪液量以及可能的泪液分泌率会出现预期的波动，但泪液的渗透压呈指数衰减，相关性相对较好。
