格雷夫斯眼病与干眼综合征之间的关系。
The relationship between Graves' ophthalmopathy and dry eye syndrome.
作者信息
Selter Jessica H, Gire Anisa I, Sikder Shameema
机构信息
Johns Hopkins School of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Clin Ophthalmol. 2014 Dec 31;9:57-62. doi: 10.2147/OPTH.S76583. eCollection 2015.
Abstract
BACKGROUND
A complex relationship between Graves' ophthalmopathy (GO) and dry eye syndrome exists. New research brings more insight into the association between these two diseases.
METHODS
A review of the literature was conducted using the query terms "Graves' Ophthalmopathy", "Thyroid Eye Disease", and "Dry Eye" in MedLine (PubMed) and Scopus. A total of 55 papers were reviewed. Case reports were excluded.
CONCLUSION
This review paper shows the close relationship between dry eye syndrome and GO. The underlying mechanisms behind their association suggest mechanical impairment of orbital muscles and immune-mediated lacrimal gland dysfunction as the causes of dry eye in GO patients. However, there are a variety of treatment options available for patients with GO with signs of dry eye, which help combat this issue.
摘要
背景
格雷夫斯眼病（GO）与干眼综合征之间存在复杂的关系。新的研究为这两种疾病之间的关联带来了更多见解。
方法
在MedLine（PubMed）和Scopus中使用检索词“格雷夫斯眼病”、“甲状腺眼病”和“干眼”对文献进行综述。共审查了55篇论文。排除病例报告。
结论
这篇综述文章显示了干眼综合征与GO之间的密切关系。它们关联背后的潜在机制表明，眼眶肌肉的机械性损伤和免疫介导的泪腺功能障碍是GO患者干眼的原因。然而，对于有干眼迹象的GO患者有多种治疗选择，这有助于解决这个问题。
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