Stokes T C, Belcher J R, Storring R A, Stevens J F, Long P, Miller A L
Invest Cell Pathol. 1980 Oct-Dec;3(4):383-7.
Carcinoembryonic antigen (CEA) was measured in the plasma by radioimmunoassay in 80 patients who were referred because of an apparently resectable lung cancer. There was no correlation between the initial CEA level and survival in patient whose tumours were found to be inoperable or had metastasized, with only 2 of 37 patients surviving longer than 2 years. Following a curative resection, the median survival for patients with initial CEA greater than 40 micrograms l-1 was 6 months compared to 14 months for those with CEA in the range 20-40 micrograms l-1, while 56 per cent of those with CEA less than 20 micrograms l-1 are still alive at 2 years. This trend was found to be highly significant (P < 0.005). Twenty-five per cent of all patients had an initial CEA greater than 40 micrograms l-1 and this was associated with a poor prognosis, despite complete surgical removal of the primary tumour. Such elevations, if discovered in the preoperative assessment, indicate a need for a thorough search for metastases.
对80例因明显可切除的肺癌前来就诊的患者，采用放射免疫分析法检测其血浆中的癌胚抗原（CEA）。在肿瘤被发现无法手术切除或已发生转移的患者中，初始CEA水平与生存率之间无相关性，37例患者中只有2例存活超过2年。根治性切除术后，初始CEA大于40微克/升的患者中位生存期为6个月，而CEA在20 - 40微克/升范围内的患者为14个月，CEA小于20微克/升的患者中有56%在2年时仍存活。这一趋势被发现具有高度显著性（P < 0.005）。所有患者中有25%的初始CEA大于40微克/升，尽管原发肿瘤已完全手术切除，但这与预后不良相关。如果在术前评估中发现这种升高现象，则表明需要彻底检查是否存在转移。
