Tsiftsis D, Jass J R, Filipe M I, Wastell C
Invest Cell Pathol. 1980 Oct-Dec;3(4):399-408.
The epithelium bordering gastric carcinoma may show altered patterns of mucin secretion. The development of adenocarcinoma in the rat stomach was studied histochemically to determine whether similar mucin changes might precede malignant transformation. Male Wistar rats were fed N-methyl-N'-nitro-N-nitrosoguanidine (83 mg/l) ad libitum for 7 months. The stomachs were examined histologically and by special methods to distinguish neutral and acid mucins. Hyperplasia was observed as an early change in both antrum and body and was characterized by lengthening of foveolae and neck zones. This was accompanied by increased acid mucin secretion. Dysplastic change began in the proliferating neck zone of hyperplastic foci. These findings suggest that altered mucus secretion may be a feature of early malignant change.
与胃癌相邻的上皮可能显示出黏蛋白分泌模式的改变。对大鼠胃腺癌的发生进行了组织化学研究，以确定类似的黏蛋白变化是否可能在恶性转化之前出现。雄性Wistar大鼠随意喂食含N-甲基-N'-硝基-N-亚硝基胍（83毫克/升）的饲料7个月。对胃进行组织学检查并采用特殊方法区分中性和酸性黏蛋白。增生是胃窦和胃体早期出现的变化，其特征是胃小凹和颈部区域延长。同时伴有酸性黏蛋白分泌增加。发育异常变化始于增生灶的增殖颈部区域。这些发现表明，黏液分泌改变可能是早期恶性变化的一个特征。
