细胞色素P450与化学致癌机制
The cytochromes P450 and mechanisms of chemical carcinogenesis.
作者信息
Parke D V
机构信息
Division of Molecular Toxicology, School of Biological Sciences, University of Surrey, Guilford, UK.
出版信息
Environ Health Perspect. 1994 Oct;102(10):852-3. doi: 10.1289/ehp.94102852.
Abstract
This article reviews mechanisms of chemical carcinogenesis, from metabolic activation and generation of reactive oxygen species by cytochromes P4511 and P4502E to DNA damage, activation of protein kinase C and ocogenes, hyperplasia, and proteoglycan changes in the cell glycocalyx and lysosomal enzymes which mediate invasion and metastasis.
摘要
本文综述了化学致癌的机制，从细胞色素P4511和P4502E的代谢激活及活性氧的产生，到DNA损伤、蛋白激酶C和癌基因的激活、细胞增生，以及细胞糖萼和溶酶体酶中蛋白聚糖的变化，这些变化介导了侵袭和转移。
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