Lewis肺癌手术与化疗联合治疗的效果
Effect of combined surgical and chemotherapeutic treatment of Lewis lung carcinoma.
作者信息
Szabó Z, Dworák O, Kopper L, Lapis K
出版信息
J Cancer Res Clin Oncol. 1980;97(2):161-6. doi: 10.1007/BF00409902.
Abstract
The effect of combined surgical and chemotherapeutic treatment on Lewis lung carcinoma was studied. The i.m. implanted primary tumor was removed on the 10th day after transplantation, and the survival of mice was registered. Cyclophosphamide proved to be the most effective among the drugs studied (Cyclophosphamide, 5-FU, DBD, CCNU, Adriamycin, Vincristin, Hexyldeoxyuridine). Using different schedules (pre- and/or post-operative treatment) the pre- and post-operative drug administration was the most advantageous. Combined therapy showed always better effect than monotherapy.
摘要
研究了手术与化疗联合治疗对Lewis肺癌的效果。移植后第10天切除经肌肉注射植入的原发性肿瘤，并记录小鼠的存活情况。在研究的药物（环磷酰胺、5-氟尿嘧啶、双溴丙脲、环己亚硝脲、阿霉素、长春新碱、己基脱氧尿苷）中，环磷酰胺被证明是最有效的。采用不同的给药方案（术前和/或术后治疗），术前和术后给药最为有利。联合治疗的效果始终优于单一疗法。
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