用1-甲基-1-亚硝基脲（MNU）和环磷酰胺联合治疗转移性脑肿瘤。
Treatment of metastatic brain tumors with the combination of 1-methyl-1-nitrosourea (MNU) and cyclophosphamide.
作者信息
Kolarić K, Roth A
出版信息
J Cancer Res Clin Oncol. 1980;97(2):193-8. doi: 10.1007/BF00409905.
Abstract
The combination of MNU and cyclophosphamide was applied in 29 consecutive previously untreated patients with metastatic brain tumors. An objective regression of the metastatic process in the brain, with seven complete and seven partial remission, was observed in 14 out of 29 patients (48%). In three patients the disease was stable, and in 12 it progressed in spite of treatment. The objective parameters used in monitoring the effect of therapy included brain scintiscan, computerized brain tomography and neurological clinical status. Median remission duration was 11.2 months in complete responders, and 5.6 months in partial responders. Median survival was also the longest in complete responders (15.7 months). The median survival of non-responding patients was only 3.1 months.
摘要
将甲硝基亚硝基胍（MNU）和环磷酰胺联合应用于29例连续的既往未经治疗的转移性脑肿瘤患者。在29例患者中的14例（48%）观察到脑转移过程的客观消退，其中7例完全缓解，7例部分缓解。3例患者病情稳定，12例患者尽管接受了治疗但病情仍进展。用于监测治疗效果的客观参数包括脑闪烁扫描、计算机断层扫描和神经学临床状态。完全缓解者的中位缓解持续时间为11.2个月，部分缓解者为5.6个月。完全缓解者的中位生存期也最长（15.7个月）。无反应患者的中位生存期仅为3.1个月。
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