Maekawa A, Matsuoka C, Onodera H, Tanigawa H, Furuta K, Ogiu T, Mitsumori K, Hayashi Y
J Cancer Res Clin Oncol. 1985;109(3):178-82. doi: 10.1007/BF00390353.
Male and female F344 rats were continuously administered N-methyl-N-nitrosourea (MNU) in their drinking water at concentrations of 200 or 100 ppm, and both sexes of ACI/N rats were given MNU at a concentration of 200 ppm. By the 42nd week of the experiment, high incidences of brain/spinal cord tumors were observed in both strains of rats. Histologically, many of them were astrocytomas or anaplastic astrocytomas. In addition, malignant neurinomas were also detected in the spinal nerve roots and trigeminal nerves, although their incidences were rather low. There was no difference in the type and incidence of these neurogenic tumors between the two strains of rats. Tumors of the tongue and esophagus were mainly observed in the high-dose group of F344 rats and those of the glandular stomach were observed in the low-dose group of F344 rats. In ACI/N rats, tumors of the heart and renal pelvis were detected. The organ-specific carcinogenicity of MNU in these two strains of rats was compared with that of MNU in Donryu rats. It was demonstrated that organ specificity of MNU given orally was influenced not only by the strain of rats but also by the dose level.
将雄性和雌性F344大鼠的饮用水中持续加入浓度为200或100 ppm的N-甲基-N-亚硝基脲（MNU），并给ACI/N大鼠两性给予浓度为200 ppm的MNU。到实验第42周时，在两种品系的大鼠中均观察到脑/脊髓肿瘤的高发生率。组织学上，其中许多是星形细胞瘤或间变性星形细胞瘤。此外，在脊神经根和三叉神经中也检测到恶性神经鞘瘤，尽管其发生率相当低。两种品系大鼠之间这些神经源性肿瘤的类型和发生率没有差异。舌和食管肿瘤主要在高剂量组的F344大鼠中观察到，而腺胃肿瘤在低剂量组的F344大鼠中观察到。在ACI/N大鼠中，检测到心脏和肾盂肿瘤。将MNU在这两种品系大鼠中的器官特异性致癌性与MNU在唐育大鼠中的进行比较。结果表明，口服MNU的器官特异性不仅受大鼠品系影响，还受剂量水平影响。
