实际的新型致癌肼类、酰肼类和腙类化合物。
Actual new cancer-causing hydrazines, hydrazides, and hydrazones.
作者信息
Toth B
出版信息
J Cancer Res Clin Oncol. 1980;97(2):97-108. doi: 10.1007/BF00409895.
Abstract
Twenty actual new cancer-causing hydrazines, hydrazides, and hydrazones of synthetic or natural origin are described. These compounds induce tumors in various target tissues in mice, hamsters and rats. To nine of these compounds the human population is exposed in the form of drugs, agricultural herbicides, and naturally occurring ingredients of edible mushrooms. Yet, with one exception, none of the hydrazines described here were investigated for cancer-inducing abilities in man. The human population should be warned against the use of this hazardous class of chemicals, the total number of which is now 40.
摘要
本文描述了20种实际存在的、具有致癌性的肼类、酰肼类和腙类化合物，它们或是合成的，或是天然存在的。这些化合物能在小鼠、仓鼠和大鼠的各种靶组织中诱发肿瘤。人类以药物、农用除草剂以及可食用蘑菇中的天然成分等形式接触到其中的9种化合物。然而，除了一种例外情况，本文所述的肼类化合物均未针对其对人类的致癌能力进行研究。应警告人类不要使用这类危险化学品，目前这类化学品的总数为40种。
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本文引用的文献
1
Nitrogen fixation research: a key to world food?固氮研究：解决全球粮食问题的关键？
Science. 1975 May 9;188(4188):633-43. doi: 10.1126/science.188.4188.633.
2
ISOLATION AND STRUCTURE OF AGARITINE, A GAMMA-GLUTAMYL-SUBSTITUTED ARYLHYDRAZINE DERIVATIVE FROM AGARICACEAE.
J Biol Chem. 1964 Jul;239:2267-73.
3
[Experimental studies on the carcinogenic effects of isonicotinic acid hydrazide (INH)].[异烟肼（INH）致癌作用的实验研究]
Tuberkulozis. 1957 Mar-Apr;10(3-4):49-54.
4
Isoniazid therapy in relation to later occurrence of cancer in adults and in infants.异烟肼治疗与成人及婴儿后期癌症发生的关系。
Br Med J. 1967 Jun 24;2(5555):792-5. doi: 10.1136/bmj.2.5555.792.
5
Carcinogenesis in Swiss mice by isonicotinic acid hydrazide.异烟肼诱导瑞士小鼠发生癌变。
Cancer Res. 1966 Jul;26(7):1473-5.
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J Natl Cancer Inst. 1968 Aug;41(2):331-49.
7
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8
9
The carcinogenic activity of some 5-nitrofuran derivatives in the rat.
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