酰肼类化合物：药物化学中的强大工具——合成、反应性及生物学应用

Hydrazides as Powerful Tools in Medicinal Chemistry: Synthesis, Reactivity, and Biological Applications.

作者信息

Teixeira Sofia, Castanheira Elisabete M S, Carvalho M Alice

机构信息

Centre of Chemistry of University of Minho (CQ-UM), Campus de Gualtar, 4710-057 Braga, Portugal.

Centre of Physics of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.

出版信息

Molecules. 2025 Jul 3;30(13):2852. doi: 10.3390/molecules30132852.

DOI:10.3390/molecules30132852

PMID:40649366

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12251600/

Abstract

The increase in drug resistance and the high toxicity of current drugs have inspired the scientific community to develop new drugs for various diseases. Hydrazides have become an attractive functional group to easily obtain a plethora of novel compounds with a broad range of biological activities. This review, which contains studies in the literature from the previous five years, focuses on the synthesis methods and biological applications of hydrazides and their derivatives. Here, the details of the experimental reaction conditions used for the synthesis of hydrazides and their derivatives (hydrazide-hydrazones and heterocycle derivatives) are presented, as well as the purification methods and the biological activity of the synthesized compounds.

摘要

耐药性的增加以及当前药物的高毒性促使科学界研发针对各种疾病的新药。酰肼已成为一个有吸引力的官能团，能够轻松获得大量具有广泛生物活性的新型化合物。这篇综述涵盖了过去五年文献中的研究，重点关注酰肼及其衍生物的合成方法和生物应用。本文介绍了用于合成酰肼及其衍生物（酰肼腙和杂环衍生物）的实验反应条件细节，以及合成化合物的纯化方法和生物活性。