Le Marec B, Defawe G, Mention J E, Picard F, Duval J M, Dubois J
J Gynecol Obstet Biol Reprod (Paris). 1980;9(6):655-7.
The authors were able to confirm when dealing with a case of severe intra-uterine growth retardation that they were dealing with a case of trisomy 18 when they suspected a positive sign of growth retardation and carried out a pre-natal diagnostic test at the 32nd week of the pregnancy. They point out that this new indication could avoid unnecessary Caesarean operations.