Clagett G P, Russo M, Hufnagel H
J Lab Clin Med. 1981 Mar;97(3):360-8.
An experimental preparation was developed to assess changes in surface-induced arterial thrombosis in nine dogs with woven Dacron aortic prostheses. The preparation consisted in measuring the occlusion time of an A-V shunt with controlled flow rate (200 mg/min). This measurement depended on formation of an occlusive, platelet-rich thrombus on a diaphragm of polyester mesh. Two to 6 months after placement of thoracoabdominal aortic prostheses, all animals demonstrated striking prolongation of A-V shung occlusion time. This occurred in the presence and absence of heparin anticoagulation. No change in A-V shunt occlusion time was noted in dogs who had sham operations. These findings complement out studies showing biochemical and functional changes in circulating platelets in dogs with aortic prostheses, and together they are consistent with mild platelet damage sufficient to impair surface-induced thrombosis. They also support our contention than, in dogs, platelets interact reversibly with prosthetic surfaces.
为评估植入编织涤纶主动脉假体的9只犬的表面诱导动脉血栓形成的变化，开发了一种实验制剂。该制剂包括测量具有可控流速（200毫克/分钟）的动静脉分流的闭塞时间。该测量取决于在聚酯网隔膜上形成闭塞性、富含血小板的血栓。在植入胸腹主动脉假体2至6个月后，所有动物的动静脉分流闭塞时间均显著延长。无论是否进行肝素抗凝，均出现这种情况。接受假手术的犬的动静脉分流闭塞时间没有变化。这些发现补充了我们的研究，该研究显示了植入主动脉假体的犬循环血小板的生化和功能变化，并且这些发现共同表明存在足以损害表面诱导血栓形成的轻度血小板损伤。它们还支持我们的观点，即在犬中，血小板与假体表面可逆地相互作用。
