Reyers I, Mussoni L, Donati M B, de Gaetano G
Thromb Haemost. 1981 Aug 28;46(2):558-60.
This study shows that experimentally-induced immune thrombocytopenia significantly delayed occlusion of an arterial prosthesis inserted in rat abdominal aorta. Thrombocytopenia was effective when induced several hours or shortly, or even several hours after the insertion of the prosthesis. Maintenance of severe thrombocytopenia by daily administrations of antiplatelet antiserum appeared to further delay thrombotic occlusion. However, though delayed, occlusion eventually occurred in all rats, even in those with very low platelet count. This would imply that any attempt to prevent arterial prosthesis thrombosis solely by interfering with platelets is ultimately bound to fail.
本研究表明，实验性诱导的免疫性血小板减少症显著延迟了植入大鼠腹主动脉的动脉假体的闭塞。当在假体植入后数小时、不久后甚至数小时诱导血小板减少时，其是有效的。通过每日给予抗血小板抗血清维持严重血小板减少症似乎进一步延迟了血栓闭塞。然而，尽管延迟，但所有大鼠最终都会发生闭塞，即使是血小板计数非常低的大鼠。这意味着仅通过干扰血小板来预防动脉假体血栓形成的任何尝试最终都注定会失败。
