Moore G S, Calabrese E J
J Environ Pathol Toxicol. 1980 Sep;4(2-3):271-9.
Although humans may accept fairly large amounts of orally ingested copper (0.25 to 1.0 gm) without visible harmful effects, patients with Wilson's disease, and persons with G6PD deficiency may represent persons at unusual risk to hemolytic anemia from ingestion of Cu(II). This study reports that in vitro exposure of G6PD deficient red blood cells to copper produced marked elevations of methemoglobin and decreases in GSH when compared with normal red cells. Chlorite, a by-product of chlorine dioxide disinfection of water, produced decreases in GSH and G6PD activity, while increasing methemoglobin levels markedly over red cells with normal G6PD activity. The combined action of chlorite and copper was additive in producing increased levels of hemoglobin and decreases in levels of GSH and G6PD deficient cells. The combined ingestion of copper and chlorite may represent an increased risk to persons with G6PD deficiency.
尽管人类可以口服相当大量的铜（0.25至1.0克）而无明显有害影响，但患有威尔逊氏病的患者以及葡萄糖-6-磷酸脱氢酶（G6PD）缺乏者可能因摄入二价铜而面临溶血性贫血的特殊风险。本研究报告称，与正常红细胞相比，G6PD缺乏的红细胞在体外暴露于铜时会导致高铁血红蛋白显著升高和谷胱甘肽（GSH）降低。亚氯酸盐是水的二氧化氯消毒的副产物，它会使GSH和G6PD活性降低，同时与具有正常G6PD活性的红细胞相比，显著提高高铁血红蛋白水平。亚氯酸盐和铜的联合作用在增加血红蛋白水平以及降低GSH水平和G6PD缺乏细胞数量方面具有相加效应。铜和亚氯酸盐的联合摄入可能会增加G6PD缺乏者的风险。
